Endocrine Abstracts

Introduction: Hyperthyroidism is an endocrine condition with multiple causes. Paraneoplastic hyperthyroidism due to marked overproduction of human chorionic gonadotropin (hCG) by choriocarcinoma is a rare diagnosis, which results from the homology of the alpha subunit of hCG to TSH.Clinical case: A 33-year-old man, with a history of cryptorchidism and orchidopexy in infancy and a euthyroid thyroid nodule, presented with nausea, constipation, and abdomina...

Introduction: The clinical presentation of ectopic Cushing’s syndrome secondary to pheochromocytoma differs from the classic manifestations of these endocrinopathies separately. This cosecretion causes greater morbidity, requiring a complex preoperative preparation. We describe two clinical cases, a 46-year-old male with grade II overweight and a 65-year-old female with grade I obesity, both with a personal history of hypertension poorly controlled with 7 and 3 antihypert...

Background and objective: Papillary thyroid microcarcinoma (PTMC) is recognized as a separate entity by the World Health Organization. Biological behaviour and clinical outcomes of PTMC are heterogenous. Presence of lymph node metastases (LNM) in this group of patients increases the risk of recurrence and makes optimal management in PTMC controversial (observation, lobectomy with or without preventive central ipsilateral dissection). The aim of this study was to describe risk ...

Objective: This study reviews the clinical characteristics of patients treated in a Multidisciplinary Diabetic Foot Unit (MDFU) and analyzes the rate of diabetic foot amputations and the risk factors associated.Design and methods: A retrospective cohort study including data from all patients who attended the MDFU during December 2017-October 2018 period. The patients were followed until January 2019. Clinical, anthropometric, and biochemical parameters (...

Introduction: Bariatric surgery (BS) has emerged as the most effective treatment for severe obesity, but weight regain after surgery is an important issue. The aim of this study was to evaluate the impact of different surgical techniques on long-term dynamic weight loss pattern.Materials and methods: We retrospectively included 444 patients with BMI > 35 kg/m2 who underwent different BS techniques: Sleeve gastrectomy (SG; n: 80), ...

Insulin resistance and type II diabetes (T2D) are associated with activation of the Renin-Angiotensin-Aldosterone-System (RAAS) in part via regulation of its principal effector molecule, Angiotensin II (AngII). Endothelial cell activation leads to, among other factors, increased extracellular protein disulfide isomerase (PDI), a multifunctional protein that is critical to thrombus formation and regulation of reactive oxygen species. However, the effects of RAAS on PDI are unkn...

Introduction: Patients with germline mutations in one of the succinate dehydrogenase (SDH) genes are at substantially increased risk of developing paragangliomas (PGL) and pheochromocytomas (PCC). Mutations in SDHB are the most commonly found gene mutations in PC/PGL and are associated with younger ages at presentation, higher rates of metastases and poorer prognosis. Although familial PGL syndromes were initially thought to predispose only for PCC and PGL, other tumor types s...

Introduction: The NETTER 1 trial resulted in markedly longer progression-free survival (PFS), with preliminary evidence of an overall survival benefit. We report the results of PFS and safety of (177Lu)-DOTATATE in patients treated in our hospital between 2014 and 2016.Methods: Transversal and descriptive study of seven patients with advanced, progressive, somatostatin receptor-positive tumors who had received previous treatments. All of them were treate...

Introduction: Stroke is the second cause of death in the world and the first cause of disability. It is also the second cause of Diabetes-related death. The success of reperfusion therapies is time-dependent, with most delays being patient-related. We investigated the response to stroke in diabetic patients (DM), as their risk of stroke is increased by 1,8-6 times.Material and Methods: Consecutive patients with acute stroke or transient ischemic attack w...

Introduction: Gestational diabetes mellitus (GDM) is associated with an increase of maternal-fetal complications. Continuous glucose monitoring system (CGMS) detects postprandial hyperglycemia and hypoglycemia during 24 h.Methods: Women with GDM in gestational weeks 26–32 were allocated a CGMS (IproTM2) after diagnosis in an observational prospective study. It was analysed:- CGMS: Mean glucose and standard deviation...